To connect to Domino, you can use either a DSN or an ODBC connection string. Both of these methods use the Database's Open method.

Connect to a DSN

To connect using a DSN:

var db = new Database();
db.open("DSN=CData Domino Sys", (err) => {
    // Use the connection
});

Provide a Driver Connection String

To connect using an ODBC connection string:

var db = new Database();
db.open("DRIVER={CData ODBC Driver for Domino};Server=https://domino.corp.com;Database=names.nsf;Port=3002;SSLClientCertType=PEMKEY_FILE;SSLClientCert=full_path_of_certificate.pem;SSLServerCert=*;", (err) => {
    // Use the connection
});